- Less expensive.
- Less error-prone.
- Significantly easier to perform.
Genomic Prediction provides advanced genetic testing for IVF. We have developed a novel, genome-wide molecular genotyping methodology for pre-implantation genetic testing of embryos.
Our approach reduces disease risk and improves newborn health outcomes by identifying candidate embryos for implantation which are genetically normal.
(of human disease)
New paper! Non-coding regions contribute significantly to genetic disease risk -- think twice before you opt for exome sequencing over array genotyping. Also, pleiotropy between common disease risks seems to be weak.
Titled "Utility and first clinical application of screening embryos for polygenic disease risk reduction", ORIGINAL RESEARCH ARTICLE published in Frontiers in Endocrinology
How can the benefit of PGT-P be quantified? One metric is Relative Risk Reduction, or RRR, illustrated with this example of several thousand adult siblings assembled as a type 1 diabetes high risk cohort - families with family history of the disease.
"Genomic Prediction of 16 Complex Disease Risks Including Heart Attack, Diabetes, Breast and Prostate Cancer" Louis Lello et al. 2019
"Genomic Prediction is, however, offering something more wide-ranging. It is screening embryos for almost 1m single-nucleotide polymorphisms (snps). These are places where individual genomes routinely differ from one another at the level of an individual genetic letter. Individual snp differences between people rarely have much effect. But add them up and they can raise or lower by quite a lot the likelihood of someone suffering a particular disease. Generate several embryos and snp-test them, then, and you can pick out those that you think will grow up to be the healthiest."